TA Instruments’ Isothermal Titration Calorimetry (ITC), Differential Scanning Calorimetry (DSC), and Isothermal Calorimetry systems are powerful analytical techniques for in-depth characterization of molecular binding events and structural stability. Thermodynamic binding signatures not only reveal the strength of a binding event, but the specific or nonspecific driving forces involved.

Structural stability profiles from DSC reveal strengths and weaknesses in higher order structure and define the behavior of individual domains and their interactions. The TA Instruments Affinity ITC, Nano ITC and Nano DSC provide the performance, reliability and ease-of-use required for the most demanding applications in drug discovery, protein-protein interactions, structure-function characterization and more.


Differential Scanning Calorimetry

The Nano DSC and the Multi-Cell DSC represent ultrasensitive differential scanning calorimeters with unmatched flexibility for characterizing molecular structure and stability. The Nano DSC, with fixed-in-place cells, is specifically designed to analyze in-solution samples. The Multi-Cell DSC offers three removable cells and one reference cell for maximum sample flexibility.


Isothermal Microcalorimetry

Isothermal Microcalorimetry is an extremely sensitive technique complementary to TA Instruments differential scanning calorimeters. TAM is a microcalorimeter system represented by TAM IV, TAM IV-48 and TAM Air.

Based on the pioneering Thermometric technology, TAM IV offers maximum sensitivity, flexibility, and productivity. It can be used with the most sensitive microcalorimeters and a wide variety of accessories to control the experimental conditions.

TAM IV - The World's Most Sensitive Calorimeter System : https://youtu.be/a5w4VJAExhU


Isothermal Titration Calorimetry

TA Instruments’ Affinity ITC and Nano ITC series calorimeters perform with the highest sensitivity and unmatched flexibility for the characterization of any molecular interaction. With the best baseline stability available on any ultrasensitive ITC instrument, and the easy-to-use experimental design flexibility, the data quality and reproducibility from these instruments will enhance laboratory throughput with the highest quality results.